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A “natural experiment” in cardiovascular epidemiology in the early 21st century
  1. A Sekikawa1,
  2. B Y Horiuchi2,
  3. D Edmundowicz1,
  4. H Ueshima3,
  5. J D Curb4,
  6. K Sutton-Tyrrell1,
  7. T Okamura3,
  8. T Kadowaki3,
  9. A Kashiwagi3,
  10. K Mitsunami3,
  11. K Murata3,
  12. Y Nakamura3,
  13. B L Rodriguez4,
  14. L H Kuller1
  1. 1University of Pittsburgh, Pittsburgh, USA
  2. 2Hawaii Department of Health, Honolulu, USA
  3. 3Shiga University of Medical Science, Otsu, Japan
  4. 4University of Hawaii, Honolulu, USA
  1. Correspondence to:
    Dr Akira Sekikawa, 3512 Fifth Avenue, Pittsburgh, PA, USA;


Despite similar traditional risk factors, morbidity and mortality rates from coronary heart disease in western and non-western cohorts remain substantially different. Careful study of such cohorts may help identify novel risk factors for CHD, and contribute to the formulation of new preventive strategies

  • epidemiology

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