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  • Adipocyte derived plasma protein, adiponectin, is associated with smoking status in patients with coronary artery disease

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Adipocyte derived plasma protein, adiponectin, is associated with smoking status in patients with coronary artery disease
  1. T Miyazaki,
  2. K Shimada,
  3. H Mokuno,
  4. H Daida
  1. Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan
  1. Correspondence to:
    Dr Kazunori Shimada, Department of Cardiology, Juntendo University School of Medicine, 2-1-1 Hongo Bunkyo-ku, Tokyo 113-8421, Japan;
    shimakaz{at}med.juntendo.ac.jp.

https://doi.org/10.1136/heart.89.6.663

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    It has recently been recognised that adipose tissue, which accounts for more than 10% of body weight, is not only a reservoir for energy storage, but is also an endocrine tissue.1 Adiponectin, which is structurally related to collagen, is a novel adipose specific gene product that circulates at high concentrations.2 Adiponectin has an anti-inflammatory effect on endothelial cells, inhibits the proliferation of vascular smooth muscle cells, and suppresses the conversion of macrophages to foam cells.1 Plasma adiponectin concentrations are significantly lower in obese subjects than in non-obese subjects, significantly lower in patients with coronary artery disease (CAD) than in control subjects, and associated with insulin resistance in animal models.2–,4

    Cigarette smoking is one of the major coronary risk factors for CAD. Indeed, major epidemiological prospective studies have unequivocally demonstrated the relation between cigarette smoking and CAD …

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