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Transcatheter closure of perimembranous ventricular septal defects with the Amplatzer asymmetric ventricular septal defect occluder: preliminary experience in children
  1. B D Thanopoulos,
  2. G S Tsaousis,
  3. E Karanasios,
  4. N G Eleftherakis,
  5. C Paphitis
  1. Department of Paediatric Cardiology, “Aghia Sophia” Children’s Hospital, Athens, Greece
  1. Correspondence to:
    Dr B D Thanopoulos, Department of Paediatric Cardiology, “Aghia Sophia” Children’s Hospital, Thivon and Levadias Street, Athens 115 27, Greece;


Objective: To close perimembranous ventricular septal defects (PMVSDs) in children with the new Amplatzer asymmetric ventricular septal defect occluder (AAVSDO).

Patients and design: 10 children, aged 1.5–12 years, with PMVSDs underwent transcatheter closure with the AAVSDO. The device consists of two low profile disks made of Nitinol wire mesh with a 1.5 mm connecting waist. The left disk is 5 mm towards the apex and only 0.5 mm towards the aortic valve. The right disk is 4 mm larger than the waist. The prosthesis diameter was chosen to be 1–2 mm larger than the largest diameter of the defect (determined by transoesophageal echocardiography and angled angiocardiography). A 7–8 French gauge sheath was used to deliver the AAVSDO.

Results: The PMVSD diameter ranged from 2–8 mm. The device diameter ranged from 4–8 mm. After deployment of the prosthesis there was no residual shunt in 9 of 10 patients (90%). In one patient there was a trivial residual shunt that disappeared at the three month follow up. Three patients developed transient complete left bundle branch block. No other complications were observed.

Conclusions: The AAVSDO appears to be a promising device for transcatheter closure of PMVSDs in children. Further studies are required to document its efficacy, safety, and long term results in a larger patient population.

  • perimembranous ventricular septal defects
  • transcatheter closure
  • Amplatzer VSD occluder
  • AAVSDO, Amplatzer asymmetric ventricular septal defect occluder
  • PMVSD, perimembranous ventricular septal defect
  • VSD, ventricular septal defect

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  • There were no sources of financial support

  • Presented at the 37th Annual General Meeting of The Association for European Paediatric Cardiology, Porto, 15–18 May 2002.