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From malignant mutations to malignant domains: the continuing search for prognostic significance in the mutant genes causing hypertrophic cardiomyopathy
  1. S L Van Driest1,
  2. B J Maron2,
  3. M J Ackerman1,*
  1. 1Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
  2. 2The Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, Minneapolis, Minnesota, USA
  1. Correspondence to:
    Michael J Ackerman
    MD, PhD, Sudden Death Genomics Laboratory, Mayo Clinic College of Medicine, 200 First Street SW, Guggenheim 501, Rochester, MN 55905, USA;


The genetic causes of hypertrophic cardiomyopathy are diverse and thus present challenges in the development of genetic tests to identify patients at risk

  • hypertrophic cardiomyopathy
  • genetics
  • β myosin heavy chain gene

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  • * Also Departments of Medicine and Pediatrics/Divisions of Cardiovascular Diseases and Pediatric Cardiology, Mayo Clinic College of Medicine