Article Text

Download PDFPDF

Biochemical markers of myocyte injury in heart failure
Free
  1. Y Sato1,
  2. T Kita1,
  3. Y Takatsu2,
  4. T Kimura1
  1. 1Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
  2. 2Department of Cardiovascular Medicine, Amagasaki Hospital, Japan
  1. Correspondence to:
    Dr Y Sato
    Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, 54 Kawaracho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan; cardioyskuhp.kyoto-u.ac.jp

Abstract

This review discusses the role of biochemical markers of myocyte injury in patients with chronic congestive heart failure. Heart specific assays have been developed for the measurement of cardiac troponin T (cTnT), cardiac troponin I (cTnI), heart type fatty acid binding protein (H-FABP), and myosin light chain 1 (MLC-1). Concentrations of these biochemical markers increase in the absence of ischaemic events in the subset of patients with heart failure whose long term outcomes are most adverse. The markers are easy to measure serially and it is therefore easy to follow patients without inter-observer variability. The serial clinical use of these markers, separately or in combination, will sharpen our understanding of the state of heart failure.

  • BNP, brain natriuretic peptide
  • cTnI, cardiac troponin I
  • cTnT, cardiac troponin T
  • CK, creatine kinase
  • DCM, dilated cardiomyopathy
  • H-FABP, heart type fatty acid binding protein
  • MB, myocardial band
  • MLC-1, myosin light chain 1
  • NYHA, New York Heart Association
  • heart failure
  • troponin
  • heart type fatty acid binding protein
  • myosin light chain 1
  • brain natriuretic peptide

Statistics from Altmetric.com

Footnotes

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Miscellanea
    BMJ Publishing Group Ltd and British Cardiovascular Society
  • Miscellanea
    BMJ Publishing Group Ltd and British Cardiovascular Society