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Intravascular ultrasound findings of coronary wall morphology in a patient with pseudoxanthoma elasticum
  1. K Miwa,
  2. T Higashikata,
  3. H Mabuchi
  1. Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
  1. Correspondence to:
    Dr Kenji Miwa
    Molecular Genetics of Cardiovascular Disorders, Division of Cardiovascular Medicine, Graduate school of Medical Science, Kanazawa University, Takara-machi 13-1, Kanazawa 920-8641, Japan;


Pseudoxanthoma elasticum (PXE) is an inherited disorder characterised by progressive calcification of the elastic fibres in the skin, eye, and cardiovascular system. Recently, mutations in the ATP binding cassette transporter gene (ABCC6) were identified as cause of this disease. Although patients with PXE often have coronary artery disease, little is known about the process and the mechanism of coronary artery disease in PXE. In this report, intravascular ultrasound (IVUS) imaging was performed in a female patient with PXE seven years after the onset of skin lesion to assess the coronary wall morphology in detail. IVUS showed a unique five layer appearance without acoustic shadowing along the vessel wall observed in the angiographically normal portion. These findings may reflect the earlier stage of coronary artery disease caused by PXE before calcification of the internal elastic laminae.

  • IVUS, intravascular ultrasound
  • LAD, left anterior descending coronary artery
  • PXE, pseudoxanthoma elasticum
  • ATP binding cassette transporter C6
  • calcification
  • coronary artery disease
  • intravascular ultrasound
  • pseudoxanthoma elasticum

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