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Inheritance of persistent foramen ovale and atrial septal defects and the relation to familial migraine with aura
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    PFO and migraine: pearls and pitfalls in the theorizing process

    Dear Editor,

    Wilmshurst et al.,[1] link inheritance of atrial shunts to inheritance of migraine with aura in some families. The link between migraine with aura and patent foramen ovale (PFO) appears to be gathering strength and the plea for randomized controlled trials of PFO-closure in migraine patients are beginning to appear justified.[2-4] The conclusion that closure of atrial shunts usually improves or cures...

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    Conflict of Interest:
    None declared.