Article Text

Download PDFPDF
Reduction in plasma concentrations of N terminal pro B type natriuretic peptide following percutaneous coronary intervention
  1. P R Kalra1,*,
  2. A Gomma1,*,
  3. C Daly1,
  4. J R Clague1,
  5. I B Squire2,
  6. L L Ng2,
  7. K F Fox1
  1. 1Royal Brompton Hospital and National Heart and Lung Institute, Imperial College School of Medicine, London, UK
  2. 2Department of Medicine and Therapeutics, University of Leicester, Leicester, UK
  1. Correspondence to:
    Dr Caroline Daly
    Cardiology Fellow, Royal Brompton Hospital, Sydney Street, London, SW3 6LY, UK;

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

B type natriuretic peptide (BNP) and its pro-peptide N terminal fragment (NTproBNP) are raised in conditions associated with abnormal ventricular structure and function and are independent predictors of survival in diverse clinical settings. Patients without raised baseline plasma BNP demonstrate an early, transient increase in concentrations following percutaneous coronary intervention (PCI),1 but longer term effects are unknown. Potential benefits of PCI on ventricular remodelling are likely to be greatest in patients with raised baseline plasma BNP concentrations, reflecting increased wall stress or ongoing ischaemia. We hypothesised that in patients with stable coronary disease and an elevated baseline NTproBNP, successful PCI would result in a significant reduction in the plasma concentration.


The study population was recruited from a larger prospective study of risk factors for coronary in-stent restenosis.2 To define an elevated baseline value, NTproBNP was measured in a group of 30 healthy volunteers of similar age and sex distribution (mean age 50 years, 83% male) to the patient group who had no history or clinical signs of cardiovascular disease, and underwent comprehensive non-invasive testing to exclude cardiac pathology. The 90th centile was selected as the cut-off value to define raised NTproBNP, corresponding to an NT proBNP concentration of >75 fmol/ml. Local ethics committee approval was obtained and all subjects gave written informed consent.

Twenty eight patients with …

View Full Text


  • * These authors contributed equally to this work