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Clopidogrel induced urticarial rash in a patient with left main stem percutaneous coronary intervention: management issues
  1. S K Khambekar,
  2. J Kovac,
  3. A H Gershlick
  1. Department of Cardiology, Glenfield Hospital, University Hospital of Leicester, Leicester, UK
  1. Correspondence to:
    Dr S K Khambekar
    Department of Cardiology, Glenfield Hospital, University Hospital of Leicester, Leicester LE3 9QP, UK;


Clopidogrel, an ideal treatment for prevention of subacute stent thrombosis, may not be feasible to use in every patient. Ticlopidine (plus aspirin) is a very good alternative, although the risks of life threatening neutropenia should mandate regular monitoring of blood counts. It is proposed that patients undergoing angioplasty and stenting should carry a warning card in an effort to make the public and general practitioners aware that antiplatelet treatment after angioplasty plays an important part in ensuring successful outcome.

  • antithrombotic regimen
  • clopidogrel allergy
  • left main stem angioplasty
  • ticlopidine
  • ATLAST, antiplatelet therapy alone versus lovenox plus antiplatelet therapy in patients at increased risk of stent thrombosis
  • CLASSICS, clopidogrel aspirin stent international cooperative study
  • ENTICES, enoxaparin and ticlopidine after elective stenting
  • FANTASTIC, full anticoagulation versus aspirin and ticlopidine trial
  • MATTIS, multicenter aspirin and ticlopidine trial after intracoronary stenting
  • STARS, stent antithrombotic regimen study

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