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Acute coronary syndromes: should women receive less antithrombotic medication than men?
  1. N Danchin
  1. Correspondence to:
    Professeur N Danchin
    Cardiologie, Hôpital Européen Georges Pompidou, 20 rue Leblanc, 75015 Paris, France; nicolas.danchinegp.ap-hop-paris.fr

Abstract

A recent meta-analysis of all randomised trials assessing the efficacy and safety of glycoprotein IIb/IIIa agents with acute coronary syndromes showed that there was a significant interaction with sex. Explaining this difference requires an analysis of whether it has any pathophysiological basis, whether antithrombotic medications are indeed less efficacious in women in different clinical situations, and whether there are any specific reasons that may have led to the provocative results of the meta-analysis.

  • sex
  • acute coronary syndromes
  • glycoprotein IIb/IIIa inhibitors
  • antithrombotic medications
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  • PURSUIT, platelet glycoprotein IIb/IIIa in unstable angina: receptor suppression using Integrilin therapy
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