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C Reactive protein, moderate alcohol consumption, and long term prognosis after successful coronary stenting: four year results from the GENERATION study
  1. M N Zairis1,
  2. J A Ambrose2,
  3. A G Lyras1,
  4. M A Thoma1,
  5. P K Psarogianni1,
  6. P G Psaltiras1,
  7. A D Kardoulas1,
  8. G P Bibis1,
  9. E G Pissimissis1,
  10. P C Batika1,
  11. M C DeVoe2,
  12. A A Prekates1,
  13. S G Foussas1,
  14. on behalf of the GENERATION Study Group
  1. 1Department of Cardiology, Tzanio Hospital, Piraeus, Greece
  2. 2Department of Medicine, The Comprehensive Cardiovascular Center, Saint Vincent Catholic Medical Centers, New York, USA
  1. Correspondence to:
    Dr Michael N Zairis
    273-277 Alkiviadou Street, Piraeus 18536, Greece; zairishellasnet.gr

Abstract

Objectives: To determine the impact of moderate alcohol consumption on long term prognosis after successful coronary stenting, and whether it could be related to preprocedural plasma C reactive protein (CRP).

Design: Part of the prospectively designed GENERATION study which investigated the impact of several biochemical factors, including plasma CRP, on long term prognosis after coronary stenting.

Setting: Tertiary referral centre.

Patients: 483 consecutive patients with stable or unstable coronary artery disease who underwent successful coronary stenting and were followed for up to four years. Information about alcohol consumption was collected prospectively.

Interventions: Successful coronary stenting.

Main outcome measures: The incidence of the composite end point of readmission to hospital for unstable angina, non-fatal myocardial infarction, or cardiac death, whichever occurred first.

Results: By the end of follow up the incidence of the composite end point was 22.8%. Patients with a baseline plasma CRP concentration of < 0.68 mg/dl (defined by ROC analysis) did not show any difference in the composite end point (p  =  0.9) or its components, regardless of the amount of alcohol consumed during follow up. However, among patients with plasma CRP concentration of ⩾ 0.68 mg/dl, those who drank moderately had a lower incidence of the composite end point (p < 0.001) or its components.

Conclusions: Moderate alcohol consumption may have a beneficial impact on the long term prognosis following successful coronary stenting. The extent of this effect is positively related to preprocedural inflammatory status. An anti-inflammatory action of moderate alcohol consumption cannot be excluded.

  • coronary stent
  • alcohol
  • prognosis
  • ANOVA, analysis of variation
  • CI, confidence interval
  • CRP, C reactive protein
  • HR, hazard ratio
  • GENERATION, global evaluation of new events and restenosis after stent implantation
  • HDL, high density lipoprotein
  • ROC, receiver operated characteristic curve
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