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Pharmacological modulation of the ATP sensitive potassium channels during repeated coronary occlusions: no effect on myocardial ischaemia or function
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  • Published on:
    The risk of shooting stressed myocytes with beta blockers, pinacidil and glibenclamide.

    Dear Editor,

    It would seem that the K+(atp) channel opener pinacidil and closer glibenclamide might exert their effects by deceasing and increasing respecitively the rates of ATP resynthesis [1,2]. The implication is that the primary determinants of ATP resynthesis, pH, substrate availability for oxidative phosphorylation and body temperature, are important determinants of the degree of H+(atp) channel openess a...

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    Conflict of Interest:
    None declared.
  • Published on:
    A myocyte buddy system in stressed myocardium?

    Dear Editor,

    It would seem, from Boron's [1,2] and our [3,4] data, that the ATP - dependent sodium pump located on the baso-lateral border of most cells might be exquisitely sensitive to the appearance of protons in interstitial fluid coming from contiguous cells under reductive stress. They might even respond by pumping protons into their cytosol and increasing their protonmotive force driving ATP resynthesis by...

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    Conflict of Interest:
    None declared.
  • Published on:
    Might myocardial protection be achieved by advanced perfusion with an anoxic acidic buffer?

    Dear Editor,

    These studies do not exclude the possibility that myocardial protection might be induced independently of K+(atp) changes by priming the protonmotive force needed to drive ATP resynthesis by oxidative phosphorylation [1]. It could be an important consideration for the protonmotive force might be more easily and reliably primed in advance of angioplasty by perfusing the occluded vessel being targeted...

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    Conflict of Interest:
    None declared.