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Free radicals and redox signalling in cardiovascular disease: introduction
  1. A M Shah1,
  2. K M Channon2
  1. 1Department of Cardiology, Guy’s King’s & St Thomas’s School of Medicine, King’s College London, UK;
  2. 2Department of Cardiovascular Medicine, University of Oxford, UK

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Reactive oxygen species (ROS) are highly reactive chemical species comprising both free radicals such as superoxide and non-radicals such as hydrogen peroxide. When the normal balance between ROS generation and antioxidant systems is perturbed, a state of oxidative stress is said to exist, which has traditionally been considered deleterious due to …

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