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The follow electronic only articles are published in conjunction with this issue of Heart.
Right ventricular diastolic dysfunction and patent foramen ovale causing profound cyanosis
H Shnaider, A Shiran, A Lorber
A 73 year old woman presented with profound central cyanosis and a history of a minor stroke. She had normal heart morphology, normal pulmonary artery pressure, and a normal coronary angiography. A patent foramen ovale (PFO) with a massive right to left shunt was demonstrated at the atrial level, with normal pulmonary venous saturations and Po2 values. This rare, age related case of right ventricular diastolic dysfunction in a normotensive patient revealed a generous PFO allowing a pronounced right to left shunt.
Human coronary morphology after β radiation brachytherapy of in-stent restenosis
P H Grewe, T Deneke, C Hanefeld, K-M Müller
This case report discusses the human coronary morphological findings 18 hours after brachytherapy (β radiation) of an in-stent restenosis. Brachytherapy produced aseptic inflammation of the periadventitial connective tissue integrating the vasa vasorum in the acute phase. The stent neointima eight months after stenting and acutely 18 hours after radiation consisted of the same cellular components as human stent neointima of specimen not additionally treated with radiation. No evidence of necrosis or excessive fibrotic alterations of the arterial vessel wall have been found.