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Renal dysfunction and acceleration of coronary disease
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  1. M W Yerkey1,
  2. S J Kernis1,
  3. B A Franklin1,
  4. K R Sandberg2,
  5. P A McCullough1
  1. 1Department of Medicine, Divisions of Cardiology, William Beaumont Hospital, Royal Oak, MI, USA
  2. 2Department of Medicine, Nutrition and Preventive Medicine, William Beaumont Hospital
  1. Correspondence to:
    Peter A McCullough MD
    MPH, Division of Nutrition and Preventive Medicine, William Beaumont Hospital, 4949 Coolidge Highway, Royal Oak, MI 48073, USA; pmcculloughbeaumont.edu

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The first world pandemic of obesity is driving secondary epidemics of type 2 diabetes, dysmetabolic syndrome, and hypertension. This results in increasing numbers of patients with renal disease and coronary atherosclerosis. Chronic kidney disease (CKD) accelerates the course of coronary artery disease, independent of conventional cardiac risk factors. In addition, CKD has been shown to confer inferior clinical outcomes following successful coronary revascularisation, which may be offset by arterial grafting. This article reviews the evidence for accelerated cardiovascular disease in the presence of renal disease with reference to new diagnostic and therapeutic targets.

ACCELERATED ATHEROGENESIS IN CHRONIC KIDNEY DISEASE

Tens of millions of persons worldwide have combined cardiovascular disease (CVD) and CKD.1 In the USA alone, over 300 000 individuals are on renal replacement therapy (RRT),2 which confers a five- to 40-fold increased risk of fatal cardiovascular events.3w1 w2 CKD is commonly defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2, or the presence of a raised urinary albumin to creatinine ratio > 30 mg/g on a spot urine sample. Although conventional risk factors such as hypertension, diabetes mellitus, and dyslipidaemia are commonly associated with CKD and its attendant long term CVD morbidity, these risk factors alone do not fully explain the prevalence of CVD in this population.4 Figure 1 depicts the independent and dominant effect of renal disease on coronary heart disease death rates among diabetics. Novel risk factors such as homocysteinaemia (Hcy), raised lipoprotein Lp(a), oxidative stress, endothelial dysfunction, diminished transforming growth factor β1 (TGF-β1), chronic inflammation, and vascular calcification are increasingly linked to accelerated rates of atherogenesis in the setting of CKD. Furthermore, patients with CKD have inferior clinical outcomes following percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) independent of procedural success.

Figure 1

 Risk of coronary heart disease death by gradations …

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