The detection of an ejection systolic murmur in the aortic valve region often corresponds to a diagnosis of aortic sclerosis or minor disruption of the aortic valve with associated turbulence but minimal obstruction. Aortic sclerosis has two important clinical implications. Firstly, aortic sclerosis is an antecedent to clinically significant aortic valve obstruction and, secondly, it acts as a marker of increased risk of cardiovascular events. This article reviews the evidence that aortic sclerosis is a useful adjunctive tool in cardiovascular risk stratification and that its progression to haemodynamically significant aortic stenosis is a potential focus for individual monitoring and for interventional studies.
- ACE, angiotensin converting enzyme
- ARIC, atherosclerosis risk in communities
- CT, computed tomography
- LIFE, losartan intervention for endpoint reduction in hypertension
- SPARC, stroke prevention: assessment of risk in a community
- aortic valve
- aortic stenosis
- aortic sclerosis
- cardiovascular risk
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Both authors fulfil the criteria for authorship and have no competing interests to declare.