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Fractional flow reserve for the prediction of cardiac events after coronary stent implantation: results of a multivariate analysis
  1. V Klauss1,
  2. P Erdin1,
  3. J Rieber1,
  4. M Leibig1,
  5. H-U Stempfle1,
  6. A König1,
  7. M Baylacher1,
  8. K Theisen1,
  9. M C Haufe1,
  10. G Sroczynski2,
  11. T Schiele1,
  12. U Siebert2,*
  1. 1Department of Cardiology, Medizinische Poliklinik–Innenstadt, University of Munich, Munich, Germany
  2. 2Harvard Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts, USA
  1. Correspondence to:
    Dr Volker Klauss
    Department of Cardiology, Medizinische Poliklinik–Innenstadt, University of Munich, Ziemssenstrasse 1, D-80336 Munich, Germany;


Objective: To determine the prognostic value of fractional flow reserve (FFR) measurements after coronary stent implantation including multiple clinical and angiographic parameters collected in one centre.

Methods: 119 consecutive patients were enrolled who had a stent implanted with the use of a pressure wire as a guidewire. Patients were followed up for at least six months. Any death, myocardial infarction, and target vessel revascularisation were considered major adverse cardiac events (MACE). Multivariate logistic regression was used to determine adjusted odds ratios (OR) and 95% confidence intervals (CI) for FFR and covariates.

Results: Complete follow up data were available for all 119 patients. Pre-interventional FFR increased from 0.65 (0.15) to 0.94 (0.06) (p < 0.0001) after stent implantation. Eighteen MACE (15%) occurred during follow up including 15 (12.6%) target vessel revascularisations. Final FFR was significantly higher in patients without than in patients with an event (0.95 (0.05) v 0.88 (0.08), p  =  0.001). In the multivariate logistic regression analysis, only final FFR < 0.95 (OR 6.22, 95% CI 1.79 to 21.62, p  =  0.004) and reduced left ventricular function (OR 0.95, 95% CI 092 to 0.99, p  =  0.021) remained as significant independent predictors for MACE.

Conclusion: These results including multiple parameters underline that FFR after coronary stenting is a strong and independent predictor for subsequent cardiac events after six months’ follow up.

  • FFR, fractional flow reserve
  • LV, left ventricular
  • MACE, major adverse cardiac events
  • fractional flow reserve
  • coronary stenting
  • prognosis

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  • * Also the Institute for Medical Informatics, Biometry, and Epidemiology, University of Munich