Article Text

Download PDFPDF
Mid systolic septal deceleration in hypertrophic cardiomyopathy: clinical value and insights into the pathophysiology of outflow tract obstruction by tissue Doppler echocardiography
  1. O-A Breithardt1,
  2. G Beer2,
  3. B Stolle2,
  4. F Lieder2,
  5. A Franke1,
  6. T Lawrenz2,
  7. P Hanrath1,
  8. H Kuhn2
  1. 1Medizinische Klinik I, Universitäts-Klinikum, RWTH, Aachen, Germany
  2. 2Klinik für Kardiologie und Internistische Intensivmedizin, Klinikum Bielefeld-Mitte, Akademisches Lehrkrankenhaus der Westfälischen-Wilhelms Universität Münster, Bielefeld, Germany
  1. Correspondence to:
    Ole-A Breithardt MD
    Medizinische Klinik I, Univ.-Klinikum Aachen, Pauwelsstrasse 30, D-52057 Aachen, Germany;

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Hypertrophic cardiomyopathy (HCM) is an inherited cardiac disorder characterised by abnormal left ventricular (LV) hypertrophy in the absence of severe aortic stenosis and hypertension. The presence of a dynamic gradient in the left ventricular outflow tract (LVOT) above 30 mm Hg at rest is associated with an increased mortality.1 Surgical myectomy or transcoronary ablation of septal hypertrophy (TASH) is indicated in patients with persistent symptoms and gradients > 50 mm Hg under resting or provoked conditions, despite medical treatment.2 We recently described a characteristic mid systolic septal deceleration (MSSD) pattern in the velocity trace of the basal septum obtained by tissue Doppler imaging (TDI),3 but the diagnostic value of the MSSD pattern in a larger patient population is still unknown.


Twenty six HCM patients (15 male, mean (SD) age 48 (17) years, septal wall thickness > 15 mm) were studied by transthoracic resting echocardiography (GE-Vingmed Vivid 7 Pro, Horten, Norway). In addition to the standard measurements, we analysed longitudinal septal motion by colour coded TDI from the apical view (frame rate 192 (40)/s). All data were stored digitally and analysed off line (EchoPac, GE-Vingmed, Horten, Norway). The MSSD pattern was defined by the presence of a biphasic systolic velocity curve with an early systolic …

View Full Text