Article Text

Download PDFPDF
Relation between plasma amino-terminal propeptide of procollagen type III and left ventricular longitudinal strain in essential hypertension
  1. S H Poulsen1,
  2. N H Andersen2,
  3. L Heickendorff3,
  4. C E Mogensen2
  1. 1Department of Cardiology, Skejby University Hospital, Skejby, Denmark
  2. 2Department of Diabetes & Endocrinology, Aarhus University Hospital, Aarhus, Denmark
  3. 3Department of Clinical Biochemistry, Aarhus Amtssygehus University Hospital, Aarhus, Denmark
  1. Correspondence to:
    Dr Steen H Poulsen
    Department of Cardiology, Skejby Hospital, Aarhus University Hospital, DK-8200 Aarhus N, Denmark;


Objective: To investigate whether myocardial fibrosis assessed non-invasively is related to left ventricular (LV) longitudinal systolic function in patients with essential hypertension.

Design: The study consisted of 30 control subjects and 40 patients with hypertension with normal LV ejection fraction. Tissue Doppler echocardiography was performed to assess LV longitudinal systolic strain from the apical views. Mean strain was calculated from the basal and mid segments. Plasma concentrations of the amino-terminal propeptide of type III procollagen (PIIINP) were measured.

Results: In the hypertension group, mean strain was significantly reduced (mean (SD) 13 (6)% v 21 (6)%, p < 0.01) and plasma PIIINP were increased compared with controls (3.0 (0.7) μg/l v 2.1 (0.3) μg/l, p < 0.001). A significant correlation was found between mean strain and PIIINP (r  =  −0.56, p < 0.001). In patients with abnormal diastolic filling (n  =  21) mean strain was reduced compared with patients with normal LV filling (n  =  19) (10 (6)% v 15 (6)%, p < 0.01) and the serological marker PIIINP was increased (3.5 (0.6) μg/l v 2.5 (0.5) μg/l, p < 0.001).

Conclusions: There is a significant association between the extent of myocardial fibrosis and reduced LV longitudinal contractility.

  • ACE, angiotensin converting enzyme
  • LV, left ventricular
  • PIIINP, amino-terminal propeptide of procollagen type III
  • hypertension
  • systole
  • diastole
  • strain
  • fibrosis

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.