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Xanthine oxidase inhibition for chronic heart failure: is allopurinol the next therapeutic advance in heart failure?
  1. W Doehner,
  2. S D Anker*
  1. Division of Applied Cachexia Research, Department of Cardiology, Charité Medical School, Campus Virchow-Klinikum, Berlin, Germany
  1. Correspondence to:
    Wolfram Doehner
    MD, PhD, Division of Applied Cachexia Research, Department of Cardiology, Charité, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany ;


A substantial body of evidence has accumulated to suggest a role for the xanthine oxidase metabolic pathway in the pathophysiology of chronic heart failure and other cardiovascular diseases

  • BNP, brain natriuretic peptide
  • CHF, chronic heart failure
  • NO, nitric oxide
  • XO, xanthine oxidase
  • allopurinol
  • heart failure
  • xanthine oxidoreductase

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  • * Also Department of Clinical Cardiology, National Heart & Lung Institute, Imperial College, London, UK

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