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Quantitative assessment of regional peak myocardial acceleration during isovolumic contraction and relaxation times by tissue Doppler imaging
  1. I Hashimoto1,
  2. X-K Li1,
  3. A Hejmadi Bhat1,
  4. M Jones2,
  5. D J Sahn1
  1. 1Clinical Care Center for Congenital Heart Disease, Oregon Health & Science University, Portland, Oregon, USA
  2. 2National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA
  1. Correspondence to:
    Dr David J Sahn
    L608, Pediatric Cardiology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239–3098, USA;


Objective: To examine regional wall acceleration and its relation to relaxation.

Study design: 8 sheep were examined by tissue Doppler ultrasound imaging (VingMed Vivid FiVe) in apical four chamber views to evaluate the left ventricular wall divided into six segments and the mitral annulus in two segments. Peak myocardial acceleration during isovolumic periods (pIVA) derived from tissue Doppler echocardiography was analysed during isovolumic contraction (ICT) and relaxation times (IRT) in each segment.

Interventions: After scanning at baseline, haemodynamic status was changed by administration of blood, dobutamine, and metoprolol. Changes of pIVA during IRT and ICT were compared over the four haemodynamic conditions in parallel with their peak positive and negative dP/dt measured with a high frequency manometer tipped catheter.

Results: pIVA of the basal lateral segment during ICT correlated most strongly with peak positive dP/dt (r  =  0.96, p < 0.0001) and there was good correlation between pIVA of the mitral valve annulus in the septum during IRT and peak negative dP/dt (r  =  0.80, p < 0.0001). pIVA differed significantly between the four haemodynamic conditions during ICT in all segments (p < 0.05); pIVA during IRT did not differ significantly between the four conditions.

Conclusions: pIVA of the basal lateral wall during ICT correlated most strongly with peak positive dP/dt, and pIVA of the septal mitral valve annulus during IRT correlated well with peak negative dP/dt.

  • AL, apical lateral
  • AS, apical septal
  • BL, basal lateral
  • BS, basal septal
  • ICT, isovolumic contraction time
  • IRT, isovolumic relaxation time
  • LV, left ventricular
  • ML, mid-lateral
  • MS, mid-septal
  • MVL, lateral mitral valve annulus
  • MVS, septal mitral valve annulus
  • pIVA, peak myocardial acceleration during isovolumic periods
  • TDI, tissue Doppler imaging
  • contractility
  • echocardiography
  • relaxation
  • ventricle

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  • Competing interests: David J Sahn is an occasional consultant for GE Medical Systems. We do not believe this has had any effect on the conduct of this study. None of the other authors have any conflict of interest.