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Thirty day prognosis of patients with acute pulmonary oedema complicating acute coronary syndromes
  1. J Figueras,
  2. C Peña,
  3. J Soler-Soler
  1. Unitat Coronària, Servei de Cardiologia, Hospital General Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, P Vall d’Hebron, Barcelona, Spain
  1. Correspondence to:
    Dr J Figueras
    Unitat Coronària, Servei de Cardiologia, Hospital General Universitari d’Hebron (Universitat Autònoma de Barcelona), P Vall d’Hebron 119-129, 08035 Barcelona, Spain;


Objectives: To investigate the characteristics of the acute coronary syndromes underlying acute pulmonary oedema and their 30 day prognosis.

Patients: 185 consecutive patients with acute coronary syndromes and acute pulmonary oedema admitted to a tertiary care centre.

Main outcome and measures: Clinical, ECG, echocardiographic, enzymatic, and angiographic features were prospectively investigated.

Results: Non-ST segment elevation myocardial infarction (NSTEMI) was the most frequent cause of acute pulmonary oedema (61%) followed by unstable angina (UA; 21%) and ST segment elevation myocardial infarction (STEMI; 18%). In each group, mean age was ⩾ 70 years, but NSTEMI patients were the oldest and ⩾ 65% of patients had chronic hypertension. Moreover, patients with NSTEMI and UA were older and had a higher incidence of diabetes, previous myocardial infarction, and moderate to severe mitral regurgitation but a similarly reduced ejection fraction (NSTEMI, 41%; UA, 39%; and STEMI, 39%) and increased incidence of diastolic dysfunction and rate of multivessel disease (94%, 87%, and 86%, respectively). However, patients with STEMI had a higher creatine kinase MB peak concentration (158 v 76 μg/l in the NSTEMI group, p < 0.001) and 30 day mortality (26% v 9% in the NSTEMI group and 8% in the UA group, p < 0.024). Multivariate analysis identified ejection fraction < 40% and a peak creatine kinase MB concentration > 100 μg/l as the main prognostic markers (p < 0.03).

Conclusions: Acute pulmonary oedema is mostly a complication of elderly hypertensive patients with NSTEMI or UA (82%) and with multivessel disease often associated with mitral regurgitation. On the other hand, the larger infarct size and higher mortality in patients with STEMI with a similarly reduced ejection fraction suggest a more extensive acute systolic loss.

  • ACS, acute coronary syndromes
  • CK, creatine kinase
  • LBBB, left bundle branch block
  • MI, myocardial infarction
  • MR, mitral regurgitation
  • NSTEMI, non-ST segment elevation myocardial infarction
  • STEMI, ST segment elevation myocardial infarction
  • UA, unstable angina
  • prognosis
  • unstable angina
  • acute pulmonary oedema

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