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Headache response to glyceryl trinitrate in patients with and without obstructive coronary artery disease
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  • Published on:
    Glyceryl trinitrate, headache and coronary artery disease: mechanistic and therapeutic uncertainties

    Dear Ediutor

    Hsi et al. propose absence or presence of gyceryl trinitrate (GTN)- induced headache as a possibly useful clinical tool to assist in the initial risk stratification of patients with chest pain [1]. Several issues merit attention:

    1. The mechanism of action of GTN in precipitation of headache in patients – regardless of status of the coronary circulation – is unknown.

    2. Exc...

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    Conflict of Interest:
    None declared.
  • Published on:
    Patients who complain of headaches afler sublingual nitroglycerin usually have no coronary disease

    Dear Editor,

    It is indeed very gratifying to read the report by Hsi et al.[1] that sublingual nitroglycerin (NTG) administration causes significantly more frequent headaches in patients with normal or minimally diseased coronary arteries than in patients with significant coronary artery disease (CAD). Over the years I have always felt that patients with chest pain who complained of significant headaches following s...

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    Conflict of Interest:
    None declared.