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Scientific letters
Haplotype analysis of the endothelial nitric oxide synthase gene in relation to acute myocardial infarction
  1. J Chen1,*,
  2. S Su1,
  3. J Huang1,
  4. X Zhou1,
  5. Y Wang2,
  6. R Chen2,
  7. D Gu1,*
  1. 1Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, People’s Republic of China
  2. 2Institute of Biophysics, Academia Sinica, Datun Rd 15, Beijing, 100101, People’s Republic of China
  1. Correspondence to:
    Dr Dongfeng Gu
    Division of Population Genetics and Prevention, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No 167 Beilishi Road, Beijing 100037, China; gudfyahoo.com

https://doi.org/10.1136/hrt.2004.042812

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    In addition to directly affecting the blood pressure, endothelium derived nitric oxide has been suggested to play an important part in the development of atherosclerosis. Several genetic variations in the gene encoding endothelial nitric oxide synthase (eNOS) have been reported to affect the expression of eNOS, which synthesises nitric oxide. Among them, polymorphisms in the promoter (−786T>C) and exon 7 (+894G>T) were shown to be associated with reduced vascular nitric oxide production or increased proteolytic cleavage of eNOS.1 In view of the important role of eNOS in atherogenesis these variants have been hypothesised to influence the susceptibility to atherogenesis. However, findings from different studies are inconsistent and the exact molecular effects of these polymorphisms on eNOS enzyme function and activity are still debated. We conducted a case–control study to elucidate whether polymorphisms of −786T>C and +894G>T in the eNOS gene are associated with acute myocardial infarction (AMI) in the Chinese population.

    METHODS

    The enrolment criteria of AMI cases and controls for the present study have been reported in detail previously.2 Briefly, 506 patients with a definite history of AMI from among hospitalised patients of the Fuwai Heart Hospital and Cardiovascular Institute, Beijing, were recruited between October 1997 and September 2001. A group of 506 normal …

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    Footnotes

    • ↵* Also the National Human Genome Centre, Beijing, People’s Republic of China.