Objectives: To evaluate the importance of a history of hypertension on long-term mortality in a large cohort of patients hospitalised with congestive heart failure (CHF).
Design: Retrospective analysis of 5491 consecutive patients, of whom 24% had a history of hypertension. 60% of the patients had non-systolic CHF, and 57% had ischaemic heart disease.
Setting: 38 primary, secondary and tertiary hospitals in Denmark.
Main outcome measures: Total mortality 5–8 years after inclusion in the registry.
Results: Female sex and preserved left ventricular systolic function was more common among patients with a history of hypertension. 72% of the patients died during follow up. A hypertension history did not affect mortality risk (hazard ratio (HR) 0.99, 95% confidence interval (CI) 0.92 to 1.07). Correction for differences between the normotensive and hypertensive groups at baseline in a multivariate model did not alter this result (HR 1.08, 95% CI 1.00 to 1.17, p = 0.06). The hazard ratio was similar in patients with and without a history of ischaemic heart disease. Hence, a specific effect of hypertension in the group of patients with CHF with ischaemic heart disease, as suggested in earlier studies, could not be confirmed.
Conclusion: A history of arterial hypertension did not affect mortality in patients hospitalised with CHF.
- ACE, angiotensin-converting enzyme
- CHF, congestive heart failure
- DIAMOND, Danish Investigations of Arrhythmia and Mortality
- HR, hazard ratio
- LVEF, left ventricular ejection fraction
- MERIT-HF, Metoprolol CR/XL Randomized Intervention Trial in Chronic Heart Failure
- WMI, wall motion index
Statistics from Altmetric.com
Competing interests: None declared.
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.