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Plasma brain natriuretic peptide concentrations in patients undergoing pulmonary vein isolation
  1. T Date,
  2. T Yamane,
  3. K Inada,
  4. S Matsuo,
  5. S Miyanaga,
  6. K Sugimoto,
  7. K Shibayama,
  8. I Taniguchi,
  9. S Mochizuki
  1. Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan
  1. Correspondence to:
    Dr Taro Date
    Division of Cardiology, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105-8461, Japan; datet{at}


Objective: To examine whether raised plasma brain natriuretic peptide (BNP) concentrations decrease after successful pulmonary vein isolation (PVI) in patients with atrial fibrillation (AF).

Methods: 53 patients (mean age 53 years) with drug-refractory, paroxysmal lone AF underwent segmental ostial PVI. Blood samples were collected before and after PVI. BNP concentrations were determined by immunoassays.

Results: Median plasma BNP concentrations were significantly higher in patients with lone AF than in controls (patients with supraventricular tachyarrhythmias, n  =  21) (64.6 (71.9) v 13.9 (7.8) pg/ml, p < 0.01). AF recurred in 21 patients after the initial PVI procedure (recurrent AF group), and the others were free from AF without antiarrhythmic drugs (non-recurrent AF group). BNP concentrations were significantly decreased by PVI in the non-recurrent AF group (38.9 (39.1) to 18.3 (16.1) pg/ml, p < 0.01) but not in the recurrent AF group.

Conclusions: Raised plasma BNP concentrations decreased after successful segmental ostial PVI in patients with AF.

  • AF, atrial fibrillation
  • ANP, atrial natriuretic peptide
  • BNP, brain natriuretic peptide
  • LA, left atrium
  • PV, pulmonary vein
  • PVI, pulmonary vein isolation

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  • Published Online First 28 June 2006

  • Competing interests: None declared.