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Heart review
Connexin 43 signalling and cardioprotection
  1. K Boengler,
  2. R Schulz,
  3. G Heusch
  1. Institut für Pathophysiologie, Universitätsklinikum Essen, Essen, Germany
  1. Correspondence to:
    Professor Gerd Heusch
    Institut für Pathophysiologie, Zentrum für Innere Medizin, Universitätsklinikum Essen, Hufelandstrasse 55, 45122 Essen, Germany; Gerd.heusch{at}uni-essen.de

Abstract

Connexin (Cx) 43 is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium. The Cx43 proteins are central to the cardioprotection afforded by ischaemic preconditioning (IP). The specific role of mitochondrial C×43 in protection by IP is reviewed.

  • Cx, connexin
  • IP, ischaemic preconditioning
  • PKC, protein kinase C
  • ROS, reactive oxygen species
  • TOM, translocase of the outer membrane

http://dx.doi.org/10.1136/hrt.2005.066878

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    • Published Online First 30 December 2005

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    Copyright 2006 by Heart