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Connexin 43 signalling and cardioprotection


Connexin (Cx) 43 is the predominant protein forming gap junctions and non-junctional hemichannels in ventricular myocardium. The Cx43 proteins are central to the cardioprotection afforded by ischaemic preconditioning (IP). The specific role of mitochondrial C×43 in protection by IP is reviewed.

  • Cx, connexin
  • IP, ischaemic preconditioning
  • PKC, protein kinase C
  • ROS, reactive oxygen species
  • TOM, translocase of the outer membrane

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