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Scientific letters
Arterial oxygen desaturation during sleep and atrial fibrillation
  1. T Tanigawa1,
  2. K Yamagishi1,
  3. S Sakurai1,
  4. I Muraki1,
  5. H Noda1,
  6. T Shimamoto2,
  7. H Iso3
  1. 1Department of Public Health Medicine, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
  2. 2Osaka Medical Center for Health Science and Promotion, Higashinari-ku, Osaka, Japan
  3. 3Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita-shi, Osaka, Japan
  1. Correspondence to:
    T Tanigawa
    Department of Public Health Medicine, Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1, Tennodai, Tsukuba 305-8575, Japan; Tt9178{at}aol.com

https://doi.org/10.1136/hrt.2005.081257

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    Atrial fibrillation is a common arrhythmia with associated complications of stroke and other adverse outcomes. We conducted a population-based study of 1763 Japanese men aged 40–74 years to examine the association between the frequency of nocturnal oxygen desaturation, estimated by a pulse oximeter, and the prevalence of atrial fibrillation. We found a significant association between the severity of sleep-disordered breathing (SDB) and the prevalence of atrial fibrillation; the odds ratios (ORs) were 2.47 for those with 5–15 events/h of 3% oxygen desaturation index (ODI) level and 5.66 for those with ⩾15 events/h of 3% ODI level (p for trend = 0.02).

    Although the association of SDB with atrial fibrillation has been reported in recent clinical studies,1–4 no population-based epidemiological study has examined this relationship. We investigated the association between the frequency of nocturnal oxygen desaturation and the prevalence of atrial fibrillation among community-based subjects.

    METHODS

    The subjects were 1763 Japanese men aged 40–74 years who lived in three Japanese communities. They participated in the 2000–2004 annual cardiovascular risk surveys and were recruited for the present sleep study, at a …

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    Footnotes

    • Funding: This study was supported partly by the Japanese Ministry of Education, Culture, Sports, Science and Technology (grant-in-aid for research B: 14370132), the Health and Labour Sciences Research Grant (Clinical Research for Evidence Based Medicine) and a research grant from FULHAP, Japan. The funding sources had no role in the study design, data collection, data analysis, data interpretation or writing of the report.

    • Competing interests: None declared.

    • TT, TS and HI designed the study. TT, KY, SS, HN and IM collected and analysed the data. IM and TT carried out statistical analysis of the data. HI, TT and TS coordinated the study. The manuscript was prepared mainly by TT and HI, with contributions from SS, KY and TS.