Diabetes mellitus is responsible for a spectrum of cardiovascular disease. The best known complications arise from endothelial dysfunction, oxidation, inflammation, and vascular remodelling and contribute to atherogenesis. However, the effects on the heart also relate to concurrent hypertensive heart disease, as well as direct effects of diabetes on the myocardium. Diabetic heart disease, defined as myocardial disease in patients with diabetes that cannot be ascribed to hypertension, coronary artery disease, or other known cardiac disease, is reviewed.
- BNP, brain natriuretic peptide
- HOPE, heart outcomes prevention evaluation
- HOT, hypertension optimal treatment
- LIFE, losartan intervention for endpoint reduction in hypertension
- UKPDS, UK prospective diabetes study
- diabetes mellitus
- left ventricular function
- tissue characterisation
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Published Online First 13 September 2005
This programme is supported in part by a Clinical Centre of Research Excellence award from the National Health and Medical Research Council of Australia.
Competing interests: None declared