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Diabetic heart disease


Diabetes mellitus is responsible for a spectrum of cardiovascular disease. The best known complications arise from endothelial dysfunction, oxidation, inflammation, and vascular remodelling and contribute to atherogenesis. However, the effects on the heart also relate to concurrent hypertensive heart disease, as well as direct effects of diabetes on the myocardium. Diabetic heart disease, defined as myocardial disease in patients with diabetes that cannot be ascribed to hypertension, coronary artery disease, or other known cardiac disease, is reviewed.

  • BNP, brain natriuretic peptide
  • HOPE, heart outcomes prevention evaluation
  • HOT, hypertension optimal treatment
  • LIFE, losartan intervention for endpoint reduction in hypertension
  • UKPDS, UK prospective diabetes study
  • diabetes mellitus
  • myocardium
  • left ventricular function
  • tissue characterisation

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Linked Articles

  • Miscellanea
    BMJ Publishing Group Ltd and British Cardiovascular Society
  • Miscellanea
    BMJ Publishing Group Ltd and British Cardiovascular Society