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Two female siblings (A and B) were referred for clinical screening following the sudden death of their mother aged 45 years from hypertrophic cardiomyopathy (diagnosed post-mortem). The sisters complained of fatigue, exertional dyspnoea (New York Heart Association functional class II), and infrequent palpitations. Their 12 lead ECGs are shown in panels A and B.
In patient A, the echocardiogram demonstrated asymmetric hypertrophy of the interventricular septum …