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Coronary artery remodelling is related to plaque composition
  1. G A Rodriguez-Granillo,
  2. P W Serruys,
  3. H M Garcia-Garcia,
  4. J Aoki,
  5. M Valgimigli,
  6. C A G van Mieghem,
  7. E McFadden,
  8. P P T de Jaegere,
  9. P de Feyter
  1. Thoraxcentre, Erasmus Medical Centre, Rotterdam, the Netherlands
  1. Correspondence to:
    Professor Patrick W Serruys
    Thoraxcentre, Bd-406, Dr Molewaterplein 40, 3015-GD Rotterdam, Netherlands; p.w.j.c.serruys{at}


Objective: To assess the potential relation between plaque composition and vascular remodelling by using spectral analysis of intravascular ultrasound (IVUS) radiofrequency data.

Methods and results: 41 coronary vessels with non-significant (< 50% diameter stenosis by angiography), ⩽ 20 mm, non-ostial lesions located in non-culprit vessels underwent IVUS interrogation. IVUS radiofrequency data obtained with a 30 MHz catheter, were analysed with IVUS virtual histology software. A remodelling index (RI) was calculated and divided into three groups. Lesions with RI ⩾ 1.05 were considered to have positive remodelling and lesions with RI ⩽ 0.95 were considered to have negative remodelling. Lesions with RI ⩾ 1.05 had a significantly larger lipid core than lesions with RI 0.96–1.04 and RI ⩽ 0.95 (22.1 (6.3) v 15.1 (7.6) v 6.6 (6.9), p < 0.0001). A positive correlation between lipid core and RI (r  =  0.83, p < 0.0001) and an inverse correlation between fibrous tissue and RI (r  =  −0.45, p  =  0.003) were also significant. All of the positively remodelled lesions were thin cap fibroatheroma or fibroatheromatous lesions, whereas negatively remodelled lesions had a more stable phenotype, with 64% having pathological intimal thickening, 29% being fibrocalcific lesions, and only 7% fibroatheromatous lesions (p < 0.0001).

Conclusions: In this study, in vivo plaque composition and morphology assessed by spectral analysis of IVUS radiofrequency data were related to coronary artery remodelling.

  • CSA, cross sectional area
  • IVUS, intravascular ultrasound
  • MLA, minimum lumen area
  • RI, remodelling index
  • VH, virtual histology
  • ultrasonography
  • remodelling
  • atherosclerosis
  • plaque characterisation

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  • Published Online First 17 June 2005

  • No author has any conflict of interest.

  • All authors have approved the final manuscript, which has not been published and is not under consideration elsewhere.

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