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Sources of support: Siemens Medical Solutions UK: loan of Acuson Cypress Echocardiography device. Cultech Ltd: donation of antioxidant supplement and matched placebo
Competing interests: All authors have nothing to declare
Institution(s) to which the work should be attributed: Apex (Altitude Physiological Expeditions SC030345), University of Edinburgh
The pooled data of this study were presented at the British Cardiac Society conference in 2004.
Contributions of authors: J B Irving recorded the novel finding of pericardial effusions and contributed to the manuscript; A A R Thompson and J K Baillie analysed the data and wrote the manuscript; M Toshner and J B Irving conducted echocardiography; J K Baillie, A A R Thompson, S R J Maxwell, and D J Webb designed and conducted the trial of antioxidant supplementation and contributed to the manuscript; A A R Thompson led the Apex 2 expedition.