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Abstract
The evidence base for implantable cardioverter-defibrillator (ICD) therapy requires expansion of guidance/indications to allow UK physicians to treat a broader range of patients. The ICD clinical consultees to the National Institute for Health and Clinical Excellence (NICE) review current guidance/guidelines, explain the evidence base, and suggest a UK ICD implantation strategy
- ATP, antitachycardia pacing
- AVID, antiarrhythmics versus implantable defibrillators study
- CABG Patch, coronary artery bypass graft patch trial
- CARE-HF, cardiac resynchronization-heart failure study
- CASH, cardiac arrest study Hamburg
- CIDS, Canadian implantable defibrillator study
- CRT, cardiac resynchronisation therapy
- DAVID, dual chamber and VVI implantable defibrillator trial
- DINAMIT, defibrillator in acute myocardial infarction trial
- EF, ejection fraction
- EPS, electrophysiological study
- ICD, implantable cardioverter-defibrillator
- MADIT I, multicenter automatic defibrillator implantation trial
- MADIT II, multicenter automatic defibrillator implantation trial II
- MI, myocardial infarction
- MUSTT, multicenter unsustained tachycardia trial
- NHS, National Health Service
- NICE, National Institute for Health and Clinical Excellence
- NYHA, New York Heart Association
- QoL, quality of life
- SCD, sudden cardiac death
- SCD HeFT, sudden cardiac death in heart failure trial
- VF, ventricular fibrillation
- VT, ventricular tachycardia
- cost efficacy
- implantable cardioverter-defibrillator
- ICD
- guidelines
- sudden cardiac death
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- ATP, antitachycardia pacing
- AVID, antiarrhythmics versus implantable defibrillators study
- CABG Patch, coronary artery bypass graft patch trial
- CARE-HF, cardiac resynchronization-heart failure study
- CASH, cardiac arrest study Hamburg
- CIDS, Canadian implantable defibrillator study
- CRT, cardiac resynchronisation therapy
- DAVID, dual chamber and VVI implantable defibrillator trial
- DINAMIT, defibrillator in acute myocardial infarction trial
- EF, ejection fraction
- EPS, electrophysiological study
- ICD, implantable cardioverter-defibrillator
- MADIT I, multicenter automatic defibrillator implantation trial
- MADIT II, multicenter automatic defibrillator implantation trial II
- MI, myocardial infarction
- MUSTT, multicenter unsustained tachycardia trial
- NHS, National Health Service
- NICE, National Institute for Health and Clinical Excellence
- NYHA, New York Heart Association
- QoL, quality of life
- SCD, sudden cardiac death
- SCD HeFT, sudden cardiac death in heart failure trial
- VF, ventricular fibrillation
- VT, ventricular tachycardia
Footnotes
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All authors have accepted lecture fees, research grants and sponsorship to attend meetings from ICD manufacturing companies. JMM, JCC, and AJC are paid advisers/consultants to ICD manufacturing companies.
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Potential conflicts of interests: JMM, JCC, and JMMcC advised the NICE appraisal committee on behalf of the British Cardiac Society, the Royal College of Physicians and Heart Rhythm UK (formerly the British Pacing and Electrophysiology Group). The reviews expressed in this paper are, however, their own and not necessarily those of the bodies they represented.