Article Text

Download PDFPDF
End points in clinical trials: are they moving the goalposts?
  1. D Y Leung,
  2. J K French
  1. Cardiology Department and South West Sydney Clinical School (UNSW), Liverpool Hospital, Elizabeth Street, Liverpool, NSW 2170, Australia
  1. Correspondence to:
    Professor John K French
    Department of Cardiology, Liverpool Hospital, Elizabeth Street, Liverpool, NSW 2170, Australia; j.french{at}


In selecting and defining composite end points in clinical trials, are we trading off clinical significance for statistical significance?

  • CABG, coronary artery bypass graft surgery
  • CK, creatine kinase
  • MI, myocardial infarction
  • PCI, percutaneous coronary intervention
  • clinical trials
  • coronary heart disease
  • end points

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.