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Variability of aortic stiffness is not associated with the fibrillin 1 genotype in patients with Marfan’s syndrome

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  • * Both authors contributed equally to this manuscript

  • This study was supported by a grant from the Netherlands Heart Foundation (2000.108) (G J Nollen), by a research grant from Ghent University (BOF 011D4701) (J De Backer), and by a research grant from the Fund For Scientific Research Belgium (FWO G029002) (A De Paepe).

  • The study was approved by the local ethics committees (University Hospital Ghent, Belgium and Academic Medical Centre Amsterdam, the Netherlands) and individual oral and written informed consent was obtained from each patient.