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Directional atherectomy facilitates the interventional procedure and leads to a low rate of recurrent stenosis in left anterior descending and left circumflex artery ostium stenoses: subgroup analysis of the FLEXI-CUT study
  1. J B Dahm,
  2. J Ruppert,
  3. S Hartmann,
  4. D Vogelgesang,
  5. A Hummel,
  6. S B Felix
  1. Department of Cardiology and Internal Medicine B, EMA University, Greifswald, Germany
  1. Correspondence to:
    Dr J B Dahm
    Department of Cardiology, Ernst Moritz Arndt University Greifswald, Friedrich-Loeffler-Strasse 23b, D-17487 Greifswald, Germany; dahm{at}


Objectives: To examine by retrospective analysis of data from the FLEXI-CUT monocentre registry whether atherectomy can effectively simplify complex stent implantation in ostial bifurcation lesions by reducing the procedure to stenting of the left anterior descending (LAD) or left circumflex (LCX) artery ostium alone.

Patients and methods: All patients who had been enrolled in the prospective FLEXI-CUT study (directional atherectomy with adjunctive balloon angioplasty) were retrospectively analysed on the basis of significant LAD or LCX ostial stenosis (⩾ 70% stenosis) deriving from an undiseased left main stem. The primary combined end point was the rate of target lesion revascularisation (TLR) and binary restenosis; secondary end points were procedural success and major adverse cardiac events (MACE) at the six-month follow up.

Results: Of 30 patients enrolled with significant LAD or LCX ostium stenosis, 29 were effectively treated with directional atherectomy (96.7% procedural success). All patients underwent single-vessel stenting procedures of solely the LAD or LCX ostium. At follow up, binary stenosis was 25% (6 of 24), TLR (angiographic plus clinical) 10.3% (3 of 29) and total MACE 6.9% (2 of 29).

Conclusions: Directional atherectomy with single-vessel stenting procedures facilitates the interventional treatment of LAD and LCX ostium stenosis, and leads to remarkably low TLR and binary stenosis at follow up.

  • LAD, left anterior descending artery
  • LCX, left circumflex artery
  • MACE, major adverse cardiac events
  • PCI, percutaneous coronary intervention
  • TIMI, Thrombolysis in Myocardial Infarction
  • TLR, target lesion revascularisation

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  • Published Online First 31 January 2006

  • The FLEXI-CUT monocentre study was carried out with support from a restricted grant by Guidant Corp, Santa Clara, California, USA