Article Text

Abnormalities of left atrial function after cardioversion: an atrial strain rate study
  1. L Thomas1,
  2. T Mckay1,
  3. K Byth1,
  4. T H Marwick2
  1. 1Department of Cardiology, University of Sydney/Westmead Hospital, Sydney, New South Wales, Australia
  2. 2Department of Medicine, University of Queensland/Princess Alexandra Hospital, Brisbane, Queensland, Australia
  1. Correspondence to:
    L Thomas
    Department of Cardiology, Westmead Hospital, Darcy Road, Sydney 2145, New South Wales, Australia; lizat{at}


Background and objectives: The role of atrial myocardial dysfunction after cardioversion is unclear. In a comparison of patients after successful cardioversion from chronic atrial fibrillation (CAF) and normal controls, we sought to determine whether Doppler-derived atrial strain rate (A-sr) could be used to measure global left atrial function and whether A-sr was reduced in patients with CAF.

Methods: A-sr was measured from the basal septal, lateral, inferior and anterior atrial walls from the apical four-chamber and two-chamber views in 37 patients with CAF who had been cardioverted to sinus rhythm and followed up for 6 months, and in a cohort of 37 healthy people. Conventional measures of atrial function included peak transmitral A-wave velocity, A-wave velocity time integral, atrial fraction and the left atrial ejection fraction. Doppler tissue imaging was used to estimate atrial contraction velocity (A′ velocity). In addition to amplitude parameters, the time to peak A-sr was measured from aortic valve closure.

Results: Immediately after cardioversion, A-sr in the CAF cohort (baseline) was significantly lower than in controls (mean (SD) −0.53 (0.31) v −1.6 (0.75) s−1; p<0.001); the A-sr correlated with A′ velocity (r = 0.63; p<0.001) in patients. Atrial function improved over time, with maximal change observed in the initial 4 weeks after cardioversion. The time to peak A-sr was increased in the CAF group compared with controls (0.55 (0.15) v 0.46 (0.12) s), but this failed to normalise over time.

Conclusion: A-sr is a descriptor of atrial function, which is reduced after cardioversion from CAF and subsequently recovers.

  • A-sr, atrial strain rate
  • AVC, aortic valve closure
  • BSA, body surface area
  • CAF, chronic atrial fibrillation
  • DTI, Doppler tissue imaging
  • LAEF, left atrial ejection fraction
  • LAESV, left atrial end systolic volume
  • tA-sr, time to peak A-sr
  • VTI, velocity time integral

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  • Published Online First 3 July 2006

  • Competing interests: None.

  • Ethical approval for this study was obtained from the Committee for Human Research, Westmead Hospital. The approval number for this study is HREC99/9/4.11(888). All enrolled patients provided written consent for willingness to participate in this research.

    Preliminary findings were presented at the Annual Cardiac Society meeting of Australia–New Zealand, August 2005, and at the American Heart Association annual scientific sessions, November 2005.

    The contents of this article have not been published as a part or whole in any other journal previously and at present is not under consideration in any other journal for publication.

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