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Temporal decline in the prognostic impact of a recurrent acute myocardial infarction 1985 to 2002
  1. P Buch1,
  2. S Rasmussen2,
  3. G H Gislason3,
  4. J N Rasmussen2,
  5. L Køber4,
  6. N Gadsbøll5,
  7. S Stender3,
  8. M Madsen2,
  9. C Torp-Pedersen1,
  10. S Z Abildstrom3
  1. 1Department of Cardiovascular Medicine, Bispebjerg University Hospital, Bispebjerg Bakke 23, DK-2400 Copenhagen NV, Denmark
  2. 2National Institute of Public Health, Øster Farimagsgade 5, DK-1399 Copenhagen K, Denmark
  3. 3Department of Cardiology, Gentofte University Hospital, Niels Andersens Vej 65, DK-2900 Hellerup, Denmark
  4. 4Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark
  5. 5Department of Medicine, Roskilde County Hospital, Køgevej 7–13, DK-4000 Roskilde, Denmark
  1. Correspondence to:
    Dr Pernille Buch
    Department of Cardiovascular Medicine, Bispebjerg University Hospital, Bispebjerg Bakke 23, Building 40 2400 Copenhagen NV, Denmark; pb{at}


Objective: To investigate trends in case-fatality and prognostic impact from recurrent acute myocardial infarction (re-AMI) during 1985–2002.

Design: Retrospective cohort study using nationwide administrative data from Denmark.

Settings: National registries on hospital admissions and causes of death were linked to identify patients with first AMI, re-AMI and subsequent prognosis.

Patients: Patients ⩾30 years old with a discharge diagnosis of AMI during 1985–2002 were tracked for first hospital admission for re-AMI 1 year after discharge.

Main outcome measures: One-year case-fatality.

Results: 166 472 patients were identified with a first AMI; 14 123 developed re-AMI. One-year crude case-fatality from first AMI/re-AMI was 39% versus 43% in 1985–1989 and 25% versus 29% in 2000–2002, respectively. In 1985–89, 35 795 patients survived to discharge (71%); of these 2.5% experienced reinfarction within 30 days (early reinfarction) and an additional 9.0% reinfarction within days 31–365 (late re-AMI). Re-AMI carried a poor prognosis in 1985–1989 compared to no re-AMI with age- and sex-adjusted relative risk of 1-year case-fatality of 7.5 (95% CI: 6.9 to 8.5) from early re-AMI and 11.7 (95% CI: 11.0 to 12.4) from late re-AMI. In 2000–2002, 23 552 patients (86%) survived to discharge; 4.4% had early re-AMI and 6.6% late re-AMI. Adjusted relative risk of 1-year case-fatality had declined to 2.1 (95% CI: 1.9 to 2.5) from early re-AMI and 5.6 (95% CI: 5.1 to 6.2) from late re-AMI compared to patients without reinfarction.

Conclusion: Prognosis after AMI has improved substantially during the latest two decades and extends to patients with re-AMI.

  • AMI, acute myocardial infarction
  • ICD, International Classification of Diseases
  • PCI, percutaneous coronary intervention
  • acute myocardial infarction
  • mortality
  • prognosis
  • reinfarction
  • trends

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  • Published Online First 29 August 2006

  • Financial support: This study was supported by a grant from the Danish Heart Foundation (grant number 04-10-B76-A217-22196).

  • Competing interest: None.