Objectives: To evaluate the risk of cardiovascular disease in individuals with coeliac disease (CD).
Design: Swedish national hospital-based register data were used to identify 13 358 individuals who had been diagnosed with CD (1964–2003) and 64 118 age-matched and sex-matched individuals without CD. Cox regression was used to estimate the risk of vascular disease in subjects with CD. Analyses were restricted to individuals with a follow-up of >1 year and with no vascular disease before study entry.
Results: CD was associated with myocardial infarction (HR 1.27; 95% CI 1.09 to 1.48), angina pectoris (1.46; 1.25 to 1.70), heart failure (1.41; 1.22 to 1.62), brain haemorrhage (1.40; 1.05 to 1.88) and ischaemic stroke (1.35; 1.14 to 1.60). These risk estimates were similar when analyses were restricted to adults in whom vascular disease had been listed as the main diagnosis. In post-hoc analyses, where reference individuals were restricted to inpatients, no association was found between CD and later vascular disease, except for a lower risk of heart failure (0.79; 0.68 to 0.92).
Conclusions: The positive association between CD and later vascular disease may be explained by ascertainment bias.
- AP, angina pectoris
- CD, coeliac disease
- DM, diabetes mellitus
- ICD, International Classification of Diseases
- MI, myocardial infarction
- IPR, Inpatient Register
- SEI, socioeconomic index
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.