Download PDFPDF
Comparison of clinical and economic outcomes of two antibiotic prophylaxis regimens for sternal wound infection in high-risk patients following coronary artery bypass grafting surgery: a prospective randomised double-blind controlled trial
Compose Response

Plain text

  • No HTML tags allowed.
  • Web page addresses and e-mail addresses turn into links automatically.
  • Lines and paragraphs break automatically.
Author Information
First or given name, e.g. 'Peter'.
Your last, or family, name, e.g. 'MacMoody'.
Your email address, e.g.
Your role and/or occupation, e.g. 'Orthopedic Surgeon'.
Your organization or institution (if applicable), e.g. 'Royal Free Hospital'.
Statement of Competing Interests


  • A rapid response is a moderated but not peer reviewed online response to a published article in a BMJ journal; it will not receive a DOI and will not be indexed unless it is also republished as a Letter, Correspondence or as other content. Find out more about rapid responses.
  • We intend to post all responses which are approved by the Editor, within 14 days (BMJ Journals) or 24 hours (The BMJ), however timeframes cannot be guaranteed. Responses must comply with our requirements and should contribute substantially to the topic, but it is at our absolute discretion whether we publish a response, and we reserve the right to edit or remove responses before and after publication and also republish some or all in other BMJ publications, including third party local editions in other countries and languages
  • Our requirements are stated in our rapid response terms and conditions and must be read. These include ensuring that: i) you do not include any illustrative content including tables and graphs, ii) you do not include any information that includes specifics about any patients,iii) you do not include any original data, unless it has already been published in a peer reviewed journal and you have included a reference, iv) your response is lawful, not defamatory, original and accurate, v) you declare any competing interests, vi) you understand that your name and other personal details set out in our rapid response terms and conditions will be published with any responses we publish and vii) you understand that once a response is published, we may continue to publish your response and/or edit or remove it in the future.
  • By submitting this rapid response you are agreeing to our terms and conditions for rapid responses and understand that your personal data will be processed in accordance with those terms and our privacy notice.
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.

Vertical Tabs

Other responses

Jump to comment:

  • Published on:
    Authors Response
    • Shane George
    • Other Contributors:
      • Kay Dhadwal, Sharif Al-Ruzzeh, Thanos Athanasiou, Marina Choudhury, Paris Tekkis, Pynee Vuddamalay, Haifa Lyster and Mohamed Amrani

    Dear Editor,

    We thank Drs Mclaren et al. for their interest in our study.

    Firstly, we chose Vancomycin as we wished to use an antistaphylococcal drug that had been studied in cardiac surgical patients. Additional rifampicin was used in an attempt to prevent resistance developing. Clearly the strategy was successful as we did not see any increase in resistant organisms during, or for the 2 years after,...

    Show More
    Conflict of Interest:
    None declared.
  • Published on:
    Antibiotic prophylaxis in cardiac surgery
    • Graeme MacLaren, Intensivist
    • Other Contributors:
      • Siang Fei Yeoh and Denis Spelman

    Dear Editor,

    The recent study by Dhadwal et al. (1) has a number of weaknesses which merit discussion. The study appears to have been initiated by a “perceived increase in crude infection rates” but the organisms responsible for this increase were not presented. Unless there was a high incidence of infection with resistant organisms such as methicillin- resistant Staphylococcus aureus (MRSA) prior to study comme...

    Show More
    Conflict of Interest:
    None declared.