Comparison of clinical and economic outcomes of two antibiotic prophylaxis regimens for sternal wound infection in high-risk patients following coronary artery bypass grafting surgery: a prospective randomised double-blind controlled trial
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We thank Drs Mclaren et al. for their interest in our study.
Firstly, we chose Vancomycin as we wished to use an antistaphylococcal drug that had been studied in cardiac surgical patients. Additional rifampicin was used in an attempt to prevent resistance developing. Clearly the strategy was successful as we did not see any increase in resistant organisms during, or for the 2 years after,...
The recent study by Dhadwal et al. (1) has a number of weaknesses which merit discussion. The study appears to have been initiated by a “perceived increase in crude infection rates” but the organisms responsible for this increase were not presented. Unless there was a high incidence of infection with resistant organisms such as methicillin- resistant Staphylococcus aureus (MRSA) prior to study comme...