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Association of rs2200733 at 4q25 with atrial flutter/fibrillation diseases in an Italian population
  1. C Viviani Anselmi1,
  2. V Novelli1,
  3. R Roncarati1,
  4. A Malovini1,2,
  5. R Bellazzi2,
  6. R Bronzini1,
  7. G Marchese1,
  8. G Condorelli1,
  9. A S Montenero1,
  10. A A Puca1
  1. 1
    Istituto Ricovero Cura Carattere Scientifico “Multimedica”, Milan, Italy
  2. 2
    University of Pavia, Pavia, Italy
  1. Dr A A Puca, Unit of Genetics and Cardiovascular Research Institute, IRCCS Policlinico MultiMedica, Via Milanese 300, 20099 Sesto S Giovanni, Italy; puca{at}


Background: Atrial fibrillation (AF) and atrial flutter (AFL) are common cardiac conduction disorders affecting many people. Recent studies on sporadic cases of AF/AFL showed a significant association of the single nucleotide polymorphism rs2200733T with the disease, suggesting a genetic factor in the development of the disease.

Objectives: To determine the association of rs2200733 with AF/AFL derived from an Italian population sample.

Subjects: 78 patients with AF/AFL and 348 controls took part in the study.

Design: Genetic case–control study.

Results: The results indicate that there is a positive, significant association between the rs2200733 T allele and patients with AF/AFL of Italian origin (allelic p<0.001 with OR = 2.17).

Conclusion: These results derived from a sample of the Italian population agree with previously reported findings from an Icelandic study, which also found that the minor allele rs2200733 was associated with AF/AFL disease.

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  • Competing interests: None for this manuscript. However, for purposes of complete transparency, AAP has a non-funding affiliation with Elixir Pharmaceuticals.

  • Funding: Italian Ministry of Health (1% funds), Italian Ministry of Research and University (FIRB). VN and RR are supported by a fellowship of the Doctorate School of Molecular Medicine, University of Milan, Italy.

  • Ethics approval: Ethics approval was obtained.