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Researchers in the TARGET (Therapeutic Arthritis Research and Gastrointestinal Event Trial) study urge caution in giving cyclo-oxygenase (COX)-2 inhibitors and non-selective NSAIDs, especially ibuprofen, for osteoarthritis to patients at high cardiovascular (CVR) risk.
The trial suggests that these agents raise the risk, though a long term placebo controlled randomised trial …
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