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Interventional cardiology
Incidence of aortic valve regurgitation and outcome after percutaneous closure of atrial septal defects and patent foramen ovale
  1. S P Schoen1,
  2. A Boscheri1,
  3. S A Lange1,
  4. M U Braun1,
  5. J Fuhrmann1,
  6. U Kappert2,
  7. R H Strasser1
  1. 1
    Department of Cardiology, University of Dresden, Germany
  2. 2
    Department of Cardiosurgery, University of Dresden, Germany
  1. Dr S P Schoen, Department of Cardiology, Heart Centre, University of Dresden, Fetscherstr 76, 01307 Dresden, Germany; cardiology{at}


Background: In recent years percutaneous, transcatheter closure of atrial septal defects (ASD) or patent foramen ovale (PFO) was introduced into clinical practice.

Objective: To investigate the functional effects on heart valves caused by an interatrial closure device.

Methods and results: Between 2001 and 2006, 240 consecutive patients underwent percutaneous closure of an ASD or a PFO. Heart valve functions were defined by transoesophageal echocardiography before implantation and 3, 6 and 12 months after defect closure. A successful implantation procedure was performed in 98% of patients. Sufficient closure without residual shunt was achieved in 89% of patients with ASD and in 92% of patients with PFO. An overall major complication rate of 0.8% was apparent during the observation time (mean (SD) 27 (15) months). Long-term follow-up disclosed newly developed or worsened aortic valve regurgitation (AR) in 9% of patients with ASD and in 10% of patients with PFO. A potential cause for developing AR may be overgrowth of the device by tissue, leading to changes in interatrial septal geometry and traction on the root of the non-coronary aortic cusp.

Conclusion: AR occurred in 9% of patients with closed ASD and in 10% of patients with closed PFO. Indication for closure should consider this potential complication despite an otherwise safe interventional procedure.

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  • Competing interests: None.

  • SPS and AB contributed equally to this manuscript.