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The authors’ reply:
  1. P van der Meer,
  2. D J van Veldhuisen
  1. University Medical Centre Groningen, Groningen, The Netherlands
  1. Dr P van der Meer, University Medical Centre, Gröningen, The Netherlands; p.van.der.meer{at}

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We thank Dr Geisler and colleagues for their critical review of our meta-analysis.1 We agree with the authors that the quality of the included studies varied. One study had an open-label design2; however, the vast majority …

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