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Endothelial function
Segmental coronary endothelial dysfunction in patients with minimal atherosclerosis is associated with necrotic core plaques
  1. S Lavi1,2,
  2. J-H Bae1,3,
  3. C S Rihal1,
  4. A Prasad1,
  5. G W Barsness1,
  6. R J Lennon4,
  7. D R Holmes Jr1,
  8. A Lerman1
  1. 1
    Division of Cardiovascular Diseases and the Center for Coronary Physiology and Imaging, Mayo Clinic, Rochester, Minnesota, USA
  2. 2
    Division of Cardiology, London Health Sciences Centre, London, Ontario, Canada
  3. 3
    Cardiology Division, Konyang University Hospital, Daejeon, South Korea
  4. 4
    Division of Biostatistics, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Dr Amir Lerman, Division of Cardiovascular Diseases, Mayo Clinic, Mary Brigh 4-523, First Street SW, Rochester, MN 55905, USA; Lerman.Amir{at}


Background/objective: Endothelial dysfunction and atherosclerosis are systemic disorders, but are often characterised by segmental involvement and complications. A potential mechanism for local involvement early in the disease process may be related to plaque composition. This study was designed to test the hypothesis that in patients with minimal coronary atherosclerosis, coronary artery segments with abnormal endothelial function have specific plaque characteristics.

Methods: Intravascular ultrasound (IVUS) images were obtained from 30 patients who underwent coronary endothelial function assessment. Spectral analysis of the IVUS radiofrequency data was used for assessment of plaque composition. IVUS findings of the coronary sections were compared according to the corresponding endothelial response to acetylcholine.

Results: Sections with a decrease epicardial coronary arterial diameter in response to acetylcholine had smaller baseline lumen (7.5 (2.4) mm2 vs 8.8 (3.3) mm2, p = 0.006) but larger plaque burden (37.1% (9.4%) vs 31% (7%), p = 0.003) than sections with normal endothelial response. Sections with endothelial dysfunction had larger necrotic core plaques: 0.13 (0.03–0.33) mm2 vs 0.0 (0.0–0.07), p<0.001 and more dense calcium: 0.03 (IQR 0.0–0.13) mm2 vs 0.0 (0.0–0.10) mm2, p<0.01), than those with normal endothelial response. Only necrotic core area was associated with endothelial dysfunction (p<0.001) after adjusting for other measures.

Conclusions: This study suggests that local coronary endothelial dysfunction in patients with minimal coronary atherosclerosis is associated with plaque characteristics that are typical of vulnerable plaques.

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  • SL and J-HB contributed equally to this work.

  • Funding The study was supported by grants from the NIH: NIH K24 HL-69840, NIH R01 HL-63911, HL-77131 and from Mayo and University of Minnesota: MAYO-UOFM #4 PROJ1-2.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.