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Competing interests KJ and MJSL have undertaken a Wellcome Trust-funded case-control study of drug antecedents of sudden death. MJSL has received a fee for speaking from Bayer GmbH and has received consulting fees from Galpharm and from Procter and Gamble. Consulting fees from Merck and Co Inc have been paid to the University of Birmingham. MJSL is also an honorary consultant to the WHO Collaborative Centre for International Drug monitoring in Uppsala. MJSL’s wife holds shares in GlaxoSmithKline.