Article Text

Download PDFPDF
Endothelial progenitor cells: trick or treat?
  1. Anthony Mathur
  1. Correspondence to Dr Anthony Mathur, William Harvey Research Institute, Queen Mary University of London/Barts and the London NHS Trust, London, UK; a.mathur{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

An understanding of endothelial progenitor cell (EPC) biology offers the tantalising reward of addressing some of the fundamental issues in biology relating to vascular repair as well as a potential solution to the holy grail of coronary intervention—the prevention of restenosis.

However, the paper by Mills et al in this month’s issue of Heart1 (see page 2003) raises further questions in this already complex area of research that is struggling to define a method for characterising EPCs and even the form in which they may exist.2 The work reported here uses two methods to characterise EPCs (one based on surface marker expression and the other on functional capacity) following angioplasty and, interestingly, shows that while the level of circulating “EPCs” with a functional phenotype increases, no increase is seen in the putative progenitor cells (CD34+KDR+) as characterised by surface marker expression. …

View Full Text


  • Competing interests None declared.

  • Provenance and Peer review Commissioned; not externally peer reviewed.

Linked Articles