Article Text

Download PDFPDF
“Hypersynchronisation” by tissue velocity imaging in patients with cardiac amyloidosis
  1. D Bellavia1,
  2. P A Pellikka1,
  3. T P Abraham1,
  4. G B Al-Zahrani1,
  5. A Dispenzieri2,
  6. J K Oh1,
  7. R E Espinosa1,
  8. C G Scott3,
  9. C Miyazaki1,
  10. F A Miller1
  1. 1
    Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, Minnesota, USA
  2. 2
    Department of Hematology, Mayo Clinic and Foundation, Rochester, Minnesota, USA
  3. 3
    Department of Biostatistics, Mayo Clinic and Foundation, Rochester, Minnesota, USA
  1. Dr Fletcher A Miller, Jr, Cardiovascular Division, Mayo Clinic and Foundation, Rochester, MN 55905, USA; miller.fletcher{at}


Objective: It is unknown if some patients with cardiac amyloidosis (CA) have mechanical dyssynchrony, as has been demonstrated in patients with ischaemic and dilated cardiomyopathies. The aim of this study was to assess mechanical dyssynchrony in patients with CA using tissue velocity imaging (TVI) and to define its usefulness for risk stratification.

Design and patients: We included 121 patients with primary amyloidosis and 37 age-matched and sex-matched controls. Patients were divided into two groups: 60 with advanced-CA and 61 with no-advanced-CA, according to left ventricular (LV) wall thickness and diastolic dysfunction. Dyssynchrony assessment included: (1) atrioventricular dyssynchrony (dys), (2) interventricular dys, (3) intraventricular dys assessed longitudinally, using the standard deviation of time to systolic peak velocity (Ts-SD) of the 12 basal and mid level LV segments, and (4) intraventricular dys assessed radially, using the difference in radial Ts between mid anteroseptal and mid posterior segments.

Outcome: Primary end-point was all-cause death. During a median follow-up of 13 months there were 35 events among patients.

Results: Contrary to the hypothesis, the intraventricular dys indices in advanced-CA patients were reduced compared to either the no-advanced-CA group or to controls (Ts-SD: 12.1 (9.0); 35.1 (18.6); 24.5 (14.1), respectively, p<0.001). This reduction was primarily the result of decreased ejection time (ET). Moreover, ET was the most significant predictor of survival (HR  = 0.98, p<0.001).

Conclusions: The regional timing of systolic motion measured by TVI was abnormally synchronised in the patients with advanced-CA. ET reduction plays a prominent part in this process and should be considered an essential parameter for assessment of patients with cardiac amyloidosis.

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Funding: This study was supported in part by a grant from the American Heart Association Heartland Affiliate (Grant No 0620073Z).

  • Competing interests: FAM is the primary investigator on a research protocol funded by GE Healthcare.